The lab has a long history of studies in mice aimed at uncovering the underlying genetic mechanisms of angiogenesis.  The picture below represents the variation seen in angiogenic-responsiveness to certain growth factor stimuli across different strains of mice. Information generated using assays such as the corneal micropocket is being used in genome-wide association studies (GWAS) to identify novel genes involved in the growth of new blood vessels.  Concurrently, some of these genes are being validated in zebra fish through a collaboration with The Zon Lab here at Children's.